Recent breakthrough by the Perelman School of Medicine at the University of Pennsylvania have found that an abnormal amount of a lipid protein called Prostaglandin D2 in men with androgenetic alopecia may be the cause for hair loss in men and women. The derivative of prostaglandin in a certain receptor is inhibiting hair growth in both human as well as animal subjects. Striking 8 out of 10 men under 70 male pattern baldness causes hair follicles to shrink and grow microscopic hair for a shorter time lapse than normal.
Earlier research last year found that hair from bald scalp as well as from non-bald scalp contained the same amount of stem cells as well as finding the depletion of a progenitor cell. Taking an unbiased look when searching for potential organic causes for baldness, looking at scalp tissue for bald and non-bald hair follicles, they found that in human as well as in animal subject the presence of the derivative protein was 3 times higher than found in similar haired scalp with men with male pattern baldness. Although no clinical trials are underway at this time this discovery raises expectation to bring about new hair loss treatments in men and women.
Clinical features of pattern baldness in women usually occur during early teens and late middle age. This is shown by the gradual thinning of hair over the frontal area. Usually, pattern baldness in women is not accompanied by increased shedding of hair, but unlike telogen effluvium, hair loss may be seen from the start. The scalp becomes more and more visible as the disease progresses.
Most of the time, the central part of the head widens due to diffused reduction of the hair’s density, which involves the frontal scalp and crown. Some women may experience hair loss on some small areas of the frontal scalp while others may experience the effect on the entire scalp including the areas of parietal and occipital. During hair loss, women usually retain a rim of hair along the frontal hairline.
Laboratory Evaluation
Most women with pattern baldness have normal menstruation, normal fertility, and normal endocrine function, including correct levels of circulating androgens. Therefore, they would only need extensive hormonal testing when symptoms and signs of androgen excess become really visible. Laboratory measurement of serum total or free testosterone, dehydroepiandrosterone sulfate and prolactin are appropriate when hirsutism, severe unresponsive cystic acne, virilization, or galactorrhoea are present. Measurement of serum thyrotropin, serum iron and ferritin, and complete blood count may eliminate common causes of hair loss.
Differential Diagnosis of Androgenetic Alopecia
Androgenetic alopecia in women (external link) can be confused with the former condition. This is in spite of the fact that features of chronic telogen effluvium are distinct. Anyway, horizontal sections of a scalp biopsy help to distinguish the two conditions once the ratio of terminal hairs shrinks.
Morphology
As time goes by, the hairs in pattern baldness become progressively miniaturized. These hairs include the papillae and matrices, as well as the hair shafts. However, the degree of hair loss in women is not as extreme as it is with some men. Women with pattern hair loss have a mosaic of variable-diameter hairs in the affected region of the top of the scalp. Increased spacing between hairs makes the central part appear wider over the frontal scalp compared to the occipital scalp.
In some cases, hair volume may still appear normal but the hair would stop growing to its previous length and normally results to thin distal ends. Female pattern hair loss is seen on women by visual decrease in hair density while in men, it is by baldness on the affected areas.
Treatment of Androgenetic Alopecia
Hair loss is a result of abnormal hair cycle. Because of this, it is theoretically reversible. However, the current treatment options have limits in their performance and in some cases, only small improvements in hair density can be seen. Advanced pattern baldness may already be difficult to treat because irreparable damages may have already taken place on the follicular stem cell when inflammation surrounded the bulge area of the follicle. Some systematic treatment plans for this case include:
The current treatment for pattern baldness is Minoxidil. The exact mechanism by which Minoxidil works is not known but the treatment appears to affect the hair follicle in three ways: it increases the span of time follicles spend in anagen, it rouses follicles that are in catagen and it enlarges the actual follicles.
In effect, vellus hairs enlarge and are converted to terminal hairs, and shedding is reduced.Exogenous estrogen can be used to treat pattern baldness, but this regimen is no longer much in use because of Minoxidil’s efficacy.
Finasteride has been effective on men with pattern baldness but definitely it was risky on women. This regimen is not advisable for women who are still in their childbearing age because of the presence of 5a-reductase inhibitors that may cause external genitalia abnormalities in male fetuses.
Hairstyling, teasing, coloring, permanents, and the use of hair spray are means of coping with the cosmetic effects of pattern baldness. However, when the hair loss is grave, the affected person may opt to use wigs.
Hair transplantation is another option since it has already been accepted in treating pattern baldness on men. Now, it is also being used to treat female hair loss although only a very few women go for this type of treatment because of the cost and the possible trauma that may go with it.
For those women who have encountered ineffective and unsuccessful treatments for hair loss, surgery may be another option and thus, the most suited method for them.
Did you know that 95% of pattern baldness for both men and women is caused by hormone known as dihydrotestosterone? This nasty hormone sneaks up on your hair follicles and silently kills them, and the end result is make and female pattern baldness.
Dihydrotestosterone is male hormones combination commonly found in both men and women of all ages. When an excess of this hormone is produced, it can lead directly to the loss of your hair, commonly known as genetic hair loss or male and female pattern baldness.
This DHT hormone surround your hair follicles with ha wax like substance; this will basically starve the follicles of much needed vitamins and nutrients that help them to grow healthy and strong hair. The DHT, causes your hair follicles to produced thinner and thinner and more brittle hairs until the simply fall out, and new hair are unable to replace them due to damages DHT has done to the follicle. Leaving you with those tell tale unsightly bald patches or more common in women thinning across your scalp.
But there is help in the best hair loss solution, these clinically proven formulations can and do work to stop the loss of your hair and help-grow your own natural and sexy healthy hair. These hair loss remedies use the only FDA approved ingredient on the market that can be used by both men and women and has been proven to help stop further hair loss and re-grow hair.
The topical hair loss solution goes to work ensuring your follicles receive a rich supply of hair friendly clods filled with the vitamins and nutrients needed to help those hairs grow to be strong healthy and shiny.
Combine this with the oral mineral and vitamin supplements,. and you have a winning combination for hair loss re-growth.
The vitamin and mineral supplements contain all natural ingredients and herbs with powerful DHT blocking abilities, thus ensuring your hair has the very vest chances to defeat the silent killer dihydrotestosterone.
Self-esteem and sex appeal are so closely link that a recent survey has revealed that over %24 of women have thinning hair or are experiencing hair loss completely. One of hair’s primary functions as a secondary sexual characteristic is to keep us attractive. We live in a culture of full, sexy hair being the definition of femininity and attraction. Approximately 30 million women in the US, one in four, have to deal with the emotional crisis of having thinning hair with a daily reprieve contingent on the fullness of their hair.
There are many reasons for non-genetic hair thinning or female hair loss. Hair dye and bleach is the cause for many hair loss conditions within the female populations. Music mega artist Lady Gaga for example has recently exposed the fact that she is using Rogaine for hair loss problem due to constant dyeing and bleaching of her hair. Lady Gaga, 24 year old mega pop star openly admits to have been dying her hair from a natural brunette to a platinum blond since launching her career leaving her once full head of hair thin and unhealthy.
Different treatments are recommended for hair loss; hair transplant surgery being one of them however due to over dyeing and bleaching lesser treatments might be effective such as combining Rogaine treatments with a solid regimen of low level laser therapy, like only FDA approved laser therapy is Lexington Hairmax laser comb, which is known to stimulate growth and grow thicker, fuller and overall healthier hair.
When committing to being in the public eye, are you compromising your right to having medical confidentiality Not necesarely. Beverly Hills Hair Restoration has clientele in and out of the public eye; people come form all over the world to see Dr. Kahen for his experience as well as his integrity in being able to maintain the outmost confidentiality regarding who his patients are.
As a world known Beverly Hills Hair Transplant Surgeon, Dr. John Kahen has been numerously asked about his celebrity clientele by many. Recently Dr. Kahen got a phone call from celebrity gossip and entertainment news media leader,TMZ. Due to the nature of the phone call and his commitment to the integrity of his practice, Dr. Kahen was unable to disclose to anyone including TMZ any information regarding whom he has treated for hair loss or performed hair transplant surgery on.
Beverly Hills Hair Restoration Clinic is conveniently located in the heart of Beverly Hills, California. We offer secured underground parking that is easily accessible to the elevator, which will take you straight to the safety of Dr. Kahen’s office without having to compromise your security, confidentiality and comfort before and after your surgery.
It seems like not even a month goes by without having another male celebrity share their experience with hair transplant surgery.Hair transplant clinics that are partnering up with celebrities for endorsement partnerships are a growing trend nowadays. It’s estimated that annually 10,000 men are resorting to surgical help to aid them with their hair loss and hair thinning issues. Hair-loss clinics are sprouting all over town at avery alarming rate. Professionals such as dentists are getting involved in hair replacementpractices to help restore follicular fortunes.
So, how can potential patients know if they qualify for follicular hair transplant If so, how to qualify a doctor
The qualifying factors for being a candidate for hair transplant surgery are basically two; follicular hair transplant it involves transplanting hair form areas of relative excess such as the back of the head or in some cases the sides to the top of the head. The other determining factor is being at the lower end of the scale that way you will have ample supply for the demand. Not all male hair loss meets this criterion.
Male pattern hair loss if measured in seven stages called the Norwood scale, after Dr. O’Tra Norwood, the American dermatologist who explained in the 1970’s. Men at the lower end of the scale do very well with hair transplant procedures, while men on the higher end — the demand may out strip the supply.
It’s imperative to think about the future when considering hair replacement surgery due to the fact that male patter baldness is progressive. A skillful doctor will let you know when is cool to operate and when it’s not.
A single hair transplant operation requires anywhere between 4,000 — 5,000 grafts of hair follicles. The donor hair is removed from the back of the head by a linear horizontal incision then the experienced surgical team carefully dissects each follicular unit that will the be gently placed in the tiny incisions created to be placed one by one.
This process can take hours, that is why this surgery has to be done by a qualified surgeon that has the level of experience to do this well, the hair transplant costs associated with these types of procedures have been seen as high as $60,000.
Thanks to hair transplant surgery, you don’t have to live with hair loss for the rest of your life. This article looks at four important tips that can help you get great success with the procedure.
Tip #1: Do your research, to get the right surgeon. Hair replacement surgery can give you very successful results. Many people now have full as well as natural looking hair after just one surgical session.
Tip #2: Read about the patients’ experience. With the awesome power of the Internet, there are lots of discussion groups and forums out there where you can find real-life people that have had successful transplant done. Talk to them and learn, first-hand, what they went through, their successes or failures and where to find the best surgeons. You can even view real-life before and after photos to help you decide.
Tip #3: Take the time to thoroughly research and pick a surgeon with an outstanding reputation. While there are many surgeons, not all of them have the experience and skills necessary to provide you with the results you wish to achieve. A doctor can have 20 years of experience but very little experience in new methods. Experience the doctors who practice new methods are the surgeons who provided superior and natural result.
Tip #4: Contact existing patients and get your questions answered by someone who went through the process. In doing so, you’ll obtain first-hand knowledge of how your experience will be with the surgeon you’re electing to perform hair restoration. Go through the existing patients to select the best surgeon. Patients can be relied on the most honest and informative recommendations, insuring you chose to the best hair transplant surgeon, based on skill and most importantly the results.
As simple as the above tips are they can really help you get great success with hair transplant surgery
HairDX is a genetic test that will aid the doctor in determining your hair loss pattern before it occurs aiding in determining what is the best course to follow in the treatment that will have the highest likelihood of success in hair loss prevention.
The X and Y-chromosomes determine your gender, while androgens are the hormones that determine secondary sex characteristics, which help distinguish the appearance of men from women. By performing this test and seeing the pattern in your family history as well as in your genealogy the doctor will be able to predict your predisposition for hair loss or hair thinning. In most cases by the time hair loss or thinning starts to get noticeable as much as 50% of the hair loss could have already occurred.
Is there a way to predict hair loss or thinning before this takes place Absolutely! HairDX will predict hair loss before visible signs start to make themselves visible, educated decisions can then be made to preserve the existing hair, taking in consideration that FDA approved treatments are best at preserving existing hair rather that re-growing of new hair.
For female hair loss, HairDX genetic testing will determine the CAG repeat score for women to determine the likelihood of female patter baldness, a lower CAG score (Ludwig grade II or III hair loss) means a higher risk for significant hair loss while a higher score meant the opposite. Research has show that only 2.3% of women with a CAG test score bellow 15 didn’t develop female pattern hair loss. Studies have also showed that 50% of women over the age 60 will experience some form of female pattern baldness.
Just like any other type of medical condition, for males as well as females, early detection will most definitely give you a plethora of choices when it comes to having full and healthy hair.
Most shampoos cause hair loss, SLS (Sodium Lauryl Sulfate) is a key component in 95% of shampoos that has been singled out as the culprit. Is your shampoo such a bad boy It doesn’t have to be, SLS is a potent de-greaser, leaving your hair clean by binding the grease and dirt together leaving it bouncy and clean.
The problem starts after you rinse your hair due to the residue SLS leaves by setting up camp in as well as on our scalp. Studies show that as part of the normal hair cycle the average person sheds about 100 hairs a day; leaving the hair follicle exposed to an SLS irritation causing the possible death of that follicle and not allowing for regeneration causing hair loss. SLS free shampoos AKASLES free shampoos or sulfate free shampoos are one of the hottest and trendiest products to hit the health-conscious beauty marketplace preventing hair loss. The inexpensive and powerful surfactants in SLS make this agent a cost effective choice for shampoos (as well as house hold detergents), especially the inexpensive ones. Sulfate free shampoos are unfortunately difficult to find and are often on the expensive side due to the higher quality ingredients they require.
In addition sulfate free shampoos may leave your hair feeling “different” than traditional shampoos because of the alternative surfactants usually found in plant extracts. Switching to a sulfate free shampoo might be more expensive, however it’s money well spent when you consider the health ramifications and to stop hair loss.
Stem cell cloning is not a new idea. Since 1944 it has been known that existing hair follicles have the ability to grow new hair when implanted elsewhere.
Recent research shows that bald mice can grow hair after being implanted with “blank slate” stem cells. (These are different to the embryonic stem cells that generate so much controversy).
Stem cell cloning is not real cloning in the true sense of the word. But, it is very similar because hundreds of hair follicles can be produced from just one donor follicle. (Follicular multiplication or follicular cell regeneration are more accurate terms).
Follicle hair transplant therapy is still in a stage of research and testing, and so is not yet available as an alternative to conventional hair transplants.
However, this treatment (which is also known as follicular cell implantation) will involve the following procedure — A scalp biopsy is first taken to obtain a few healthy hair follicles. (This uses a local anesthetic and takes about 30 minutes).
The extracted follicles are then dissected to obtain the papilla, each of which contains between 200 and 400 dermal papilla cells (DPC’s).
These cells are then incubated in cultures to produce hundreds of thousands of new papilla cells. This process takes about 8 weeks.
The DPC’s are then implanted (injected) into a bald area of the scalp and release cytokines (chemical signals) that tell the skin to start producing new hair follicles.
Not as simple as it sounds. A new hair follicle is made from epithelial cells. But, the growth cycle of a follicle is governed by DPC’s. So, both epithelial cells andDPC’s are needed to produce a follicle.
Also, DPC’s don’t only originate from the papilla — many migrate from the dermal sheath into the papilla during the hair growth cycle, and then migrate back out again once the cycle is complete.
The added complexity of epithelial cells and dermal sheath involvement in the process of creating new follicles has presented additional problems that must be solved if this type of therapy is ever to work successfully.
Problems with stem cell cloning and follicle hair transplants
Even though stem cell cloning for follicle hair transplants has managed to produce hair re-growth in about 70% of volunteers in one very small trial, there are several areas of difficulty concerning this “therapy of the future.”
1. The culturing technique must preserve the stem cell’s ability to reproduce hair, and ensure that a significant number of DPC’s can be grown within that culture.
2. Any hair produced must be of an acceptable standard to the client (i.e., thick, strong, healthy hair growth).
3. The implantation method must guarantee that thousands of implantations per client will produce acceptable and standardized hair growth for the client.
4. An inconsistent number of follicles may be produced — even if the same quantity of cells are injected into the scalp (i.e., as were injected into another area, or in another patient) hair growth can vary from one area to the next, and from one patient to another.
5. Normal hair growth has an even density (distribution) throughout the scalp. But, transplanted cells can lump together and then cause hair growth to be patchy.
6. Regular hair growth is directional (normally it’s in a clockwise direction around the vertex). But the hair grown from implanted cells could be at any angle. This, of course, would give a very shabby looking result that’s unacceptable to the patient.